Tissue residues of mimosine and 2,3-dihydroxypyridine after intravenous infusion in goats
T. Sahlu, R. Puchala, P. J. Reis, J. J. Davis, K. Tesfai, J. M. Fernandez, and A. A. MillamenaJournal of Animal Science 73:172-176. 1995.
Sixteen growing Alpine wethers (average BW ± 2 kg) were assigned to one of four treatments to evaluate tissue retention of the leucaena toxins mimosine (MIM) and 2,3-dihydroxypyridine (2,3-DHP). Treatments were infused i.v. for 2 d and were 1) saline control, 2) MIM (200 mg · kg BW-.75 · d-1), 2,3-DHP (200 mg · kg BW-.75 · d-1), or 4) MIM (100 mg · kg BW-.75 · d-1) + 2,3-DHP (100 mg · kg BW-.75 · d-1). Immediately after the infusion, the goats were slaughtered and tissue concentrations of MIM and 2,3-DHP were determined via HPLC. No detectable levels of either toxin were found in spleen, heart, lung, or muscle; however, appreciable amounts of MIM and 2,3-DHP were found in plasma, kidney, and liver samples. Kidney MIM content was greater (P < 0.01) than that of liver, although liver tended to retain slightly more 2,3-DHP (P > 0.05). Infusion of MIM resulted in a plasma MIM content of 30 to 54 mol/L and reduced (P < 0.01) plasma PHE and LEU. Infusion of 2,3-DHP resulted in a plasma 2,3-DHP content of 9.4 mol/L and increased plasma THR, ARG, VAL, PHE, ILE, LEU, and LYS concentrations (P < 0.10). Humans consuming offals from ruminants consuming large amounts of the leguminous forage leucaena may be exposed to appreciable quantities of MIM and 2,3-DHP.
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