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Effects of small peptides or amino acids infused to a perfused area of the skin of Angora goats on mohair growth

R. Puchala, S. G. Pierzynowski, T. Wuliji, A. L. Goetsch, T. Sahlu, M. Lachica, and S. A. Soto-Navarro

Journal of Animal Science 80:1097-1104. 2002.

The effect of infusing dipeptides or their amino acids on mohair growth of Angora goats was investigated using a skin perfusion technique. Seven Angora wethers were implanted bilaterally with silicon catheters into the superficial branches of the deep circumflex iliac artery and vein and carotid artery. The experiment consisted of three 28-d phases. In the first 14 d of Phases 1 and 3, saline was infused into deep circumflex iliac arteries supplying skin and in Phase 2 a mixture of dipeptides (methionine-leucine [Met-Leu], lysine-leucine [Lys-Leu]) was infused into the artery on one side, and free amino acids were administered on the other side. Infusion rates of peptides were 0.85 mg/h Met-Leu and 0.85 mg/h Lys-Leu in 2.4 mL saline. Infusion rates of amino acids were 0.474 mg/h Lys, 0.483 mg/h Met, and 0.743 mg/h Leu in 2.4 mL saline. A 100-cm2 area within the perfused region was used to determine mohair growth. Two weeks after the cessation of infusions, perfused areas were shorn. Clean mohair production from the dipeptide- and amino acids-perfused regions were similar (4.21 vs 4.35 g/[100 cm2/28 d], respectively). However, clean mohair production during dipeptides and amino acids infusions was greater than that observed during saline infusions (3.63 g/[100 cm2/28 d]). There were no significant differences between dipeptides and free amino acids in concentrations of various hormones and metabolites in blood from deep circumflex iliac veins. In conclusion, supplying small peptides (methionine-leucine and lysine-leucine) or their amino acids directly to the skin equally increased mohair production compared with saline. Similar blood concentrations of various hormones and metabolites suggest that small peptides were utilized by skin for mohair fiber growth via supplying free amino acids for protein synthesis; however, the exact mechanism of stimulation is unclear. In this regard, significant amounts of cysteine used in mohair fiber production may have arisen from transulfuration of infused methionine.


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