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Effect of Prolactin Administered to a Perfused Area of Skin in Angora Goats

R. Puchala, S. G. Pierzynowski, T. Wuliji, A. L. Goetsch, and T. Sahlu

E (Kika) de la Garza Institute for Goat Research, Langston University, Langston, OK

Prolactin is believed to mediate seasonal hair follicle growth cycles; therefore the effect of prolactin infusion on mohair growth of Angora goats was investigated using a skin perfusion technique. Six Angora wethers (average BW 30 ± 3 kg) were implanted bilaterally with silicon catheters into the superficial branches of the deep circumflex iliac artery and the deep circumflex iliac vein. For the first 14 d of the experiment animals were infused (2.4 mL/h) into the deep circumflex iliac arteries with prolactin (one side) and saline (other side). The infusion rate of prolactin was 221 g/d and was calculated to triple prolactin blood concentration in the perfused region. The area of skin supplied by the deep circumflex iliac artery was approximately 240 cm2. Two weeks after cessation of infusions, 100 cm2 areas within the perfused regions were shorn to determine mohair growth. Greasy and clean mohair production was decreased (P < 0.05) by prolactin compared with saline (3.79 vs 4.62 g and 3.02 vs 3.67g/100 cm2/28 d, respectively). Oxygen saturation in blood hemoglobin from deep circumflex iliac veins was greater (P < 0.02) on the side infused with prolactin than on the control side (75.1 vs 68.2 %). Higher concentrations of Met, Lys, Val, Ileu, and Leu were observed in the venous blood taken from the deep circumflex iliac vein on the side infused with prolactin compared with saline (P < 0.05). Direct skin infusion with prolactin decreased fiber synthesis and may have decreased oxygen consumption by the skin. Decreased fiber production/nutrient utilization by the skin may be due to competition for nutrients with other processes that are regulated by prolactin such as lactation or reproduction. Selection of animals with low blood prolactin or low seasonal blood prolactin variation may reduce the rest phase of fiber follicles and improve fiber production.


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